Thursday, April 5, 2012

'Katy Perry: Part Of Me' Trailer: Five Key Scenes

Trailer for upcoming 3-D concert movie shows singer hard at work and interacting with fans.
By Fallon Prinzivalli


Katy Perry in the trailer for "Katy Perry: Part Of Me"
Photo: Imagine Entertainment

It's here, KatyCats! Paramount Pictures debuted Katy Perry's "Part of Me" trailer for her 3-D concert movie Tuesday night. The trailer offers a glimpse of what audiences can expect from the film, in theaters July 5.

The movie gives fans a peek into the "Firework" singer's personal life. When Perry sat down with MTV News, she said, "Literally, this film is basically like you're seeing it from my best friend-buddy perspective." Perry's always been open with her fans, interacting with them on Twitter and holding meet-and-greets at every show. But the trailer reveals a side of Perry that's sure to be new to fans. To show you what we mean, here are five key scenes from the trailer.

Be Prepared
As a commentator says, "She outworks everyone." There are shots of Perry at the gym, trying on a costume at a fitting, rehearsing her dance moves and testing the wires and ropes for stage stunts. When fans arrive at the arena for a concert, they see the final production, but not all the hard work that went into putting the show together.

From the looks of the trailer, audiences will gain a new respect for Perry as they see just how hard she works to give a stellar performance.

"Marriage Over"
After the words "Marriage Over" flash into view via a newspaper headline, there's a heartbreaking scene of Perry looking defeated as she's hunched over her dressing-room table. It shows that while she may work hard at international superstardom, at the end of the day, she's human and emotional hardships affect her just like the rest of us. We commend Perry for sharing such a personal time in her life with her fans.

She's a Firework
The next scene of Perry shows her getting out of a car for a red-carpet event. She has overcome her failed marriage and moved on with her career. The moment is inspirational as Perry continues to take the stage and perform regardless of what's going on in her personal life. Her strength is sure to leave an impression on viewers.

The Long Journey
In between scenes of old music videos from the beginning of her career, we learn that Perry wasn't always the California princess we know and love today. She grew up in a strict Christian home and her performances were limited to church, but she continued following her dreams. After they finally seemed to be within reach, the label she signed with dropped her. We see a younger Perry pouring her heart into her music as she records a song, only to look defeated afterwards as she says in a voiceover, "I was going through some depressing dark times, but it's a journey."

Embracing Perry's "Weirdness"
We were hoping to see some behind-the-scenes footage of Perry and her spontaneity, and it looks like our wish came true! "Thank you so much for believing in my weirdness," Perry yells to the audience. She says her goal when she's performing is "just to make people smile." What follows is a montage of Perry posing with fans (one of whom is dressed up as her nerdy alter ego, Kathy Beth Terry), sticking her tongue out at the camera and busting out some awkward dance moves. Perry's fun-loving persona is a big reason fans are so drawn to her as a person. KatyCats will no doubt be pleased by whatever backstage antics this film contains.

For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.

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Flame Retardants May Create Deadlier Fires

Fire Image: Wikimedia Commons/MarcusObal

In one of the deadliest nightclub fires in American history, 100 people died at a rock concert in Rhode Island nearly a decade ago. But the biggest killer wasn't the flames; it was lethal gases released from burning sound-insulation foam and other plastics.

In a fatal bit of irony, attempts to snuff fires like this catastrophic one could be making some fires even more deadly.

New research suggests that chemicals ? brominated and chlorinated flame retardants ? that are added to upholstered furniture and other household items to stop the spread of flames increase emissions?of two?poisonous gases.

"We found that flame retardants have the undesirable effect of increasing the amounts of carbon monoxide and hydrogen cyanide released during combustion," study co-author Anna Stec, a fire specialist at the University of Central Lancashire in the United Kingdom, said in a statement.

These two gases are by far the biggest killer in fires. They are responsible for 60 to 80 percent of fire deaths, according to the National Fire Protection Assn. During the Rhode Island fire, the levels of hydrogen cyanide and carbon monoxide were high enough to kill in less than 90 seconds.

Flame retardants made of brominated or chlorinated chemicals are added to furniture cushions, carpet padding, children's car seats, plastics that encase electronics and other consumer items. Under California standards adopted in the 1970s, foam inside furniture must withstand a 12-second exposure to a small, open flame, and much of the nation?s furniture is manufactured with flame retardants to meet that standard.

However, while the chemicals may be slowing the spread of flames, when fires do occur, they may be more deadly. Few details?of?the new research from?the United Kingdom are available?since the findings?have not yet been?published. But the researchers said in one experiment, nylon containing the flame retardant brominated polystyrene released six times more hydrogen cyanide when set afire than?the same?material containing a halogen-free flame retardant.

Hydrogen cyanide is 35 times more deadly than carbon monoxide, and during a fire it can kill in as little as one minute, said Todd Shoebridge, a 30-year?fire service veteran?who is?a?captain?at?the Hickory Fire Department in North Carolina.?"It's that serious," Shoebridge said.

Both carbon monoxide and hydrogen cyanide are products of incomplete combustion. As a room on fire loses oxygen, combustion becomes less efficient and gases and smoke rapidly increase. Inhaling the toxic air becomes unavoidable for people trapped in a fire.

Brominated and chlorinated?flame retardants work by interfering with combustion, which can increase the amount of?the?gases.

The evidence "leads one to assume that these chemicals could increase fire safety concerns, not decrease them," said Heather Stapleton, an environmental chemist at Duke University who specializes in studying brominated compounds.

The new research focused on brominated polystyrene, a newer flame retardant manufactured by Albemarle Corp. and other companies. It is added to nylon for use in textiles, upholstery and electrical connectors.

These newer compounds were designed to replace older flame retardants, mostly polybrominated diphenyl ethers or PBDEs, which have been banned since 2004 because they were building up in human bodies, including breast milk. PBDEs are still found in furniture manufactured before the bans.

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Wednesday, April 4, 2012

Do Crowbars Really Need Hinges? [Tools]

The Hultafors 209 adjustable wrecking bar features a nine-point articulated claw, a rubberized grip, and claims to optimize the everyman's nail-pulling experience. But does the crowbar design require improvement? More »


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The Pittsburgh Cultural Trust Kicks-Off The Summer With Cool Jazz ...

Over 240 musicians will perform in 72 HOURS.

The Pittsburgh JazzLive International Festival (PJLIF) returns to downtown Pittsburgh?s Cultural District on June 1-3, 2012. The expansive weekend of music will include a JazzLive Crawl in 30 downtown venues, 3 outdoor stages, and feature both national and internationally renowned musicians and a visual art show.?The Pittsburgh Cultural Trust?s PJLIF is produced in cooperation with the Dollar Bank Three Rivers Arts Festival, which runs from June 1 through June 10, 2012.

?The PJLIF hits four central themes, this June,? says Janis Burley Wilson, Vice President and Director of Jazz Programs for The Pittsburgh Cultural Trust. ?First, it?s literally a jazz explosion:? 240 artists in 72 hours. Second, it?s a festival that preserves and celebrates Jazz and new music?America?s only classical music, by unifying a large audience with legendary, world-class musicians, emerging talent and commissioning new work. Third, it?s an event that enhances the regional economy, and finally the PJLIF is a happening that delivers world-class art and entertainment to the City of Pittsburgh, and is free and open to the community.?

The overarching theme for programming is ?family.?? Janis Burley Wilson says, ?Jazz appreciation is passed down through families.? Pittsburgh has families of musicians that have been trailblazers in jazz.? Also, there will be a number of families performing in the festival, brothers, sisters, children of important jazz figures of this city.?? The performances will take place in downtown restaurants, coffee shops and galleries, and on three large outdoor stages in the Cultural District. Some of the musicians featured at The PJLIF include:? Monty Alexander, Poogie Bell, The Clayton Brothers, Fort Apache with Andy & Jerry Gonzalez, Robert Glasper, Allan Harris, Lalah Hathaway,?Sean Jones, Soul Cycle, Jeff ?Tain? Watts, David Budway, Warren Wolf, and The Average White Band.The festival hires over 140 local musicians, as well.? Most of the concerts are free; however seating in restaurants for the JazzLive Crawl is available for dining patrons. In addition, Sean Jones, artist-in-residence for the new initiative, Sound & Spirit, is commissioned to write new music that will debut at the festival.

The program includes community and school workshops that involve Pittsburghers in the writing process, creating music truly inspired by the people of this city.

Founded in 1984, The Pittsburgh Cultural Trust is a non-profit arts organization whose mission is the cultural and economic revitalization of a 14-block arts and entertainment/residential neighborhood called the Cultural District. Over a period of 25 years, the Trust has restored historic theaters, constructed new performance venues, commissioned public art projects/galleries and developed unique urban parks and riverfront recreation spaces. The Cultural Trust is recognized across America as a unique model of how public-private partnerships can reinvent a city with authenticity, innovation and creativity.

The Pittsburgh JazzLive International weekend is presented with support from Highmark Blue Cross Blue Shield, Macy?s, Savoy Restaurant, the City of Pittsburgh and many in-kind sponsors.?All artists and show times are subject to change. Please visit pittsburghjazzlive.com or call 412-456-6666 for updates and information.

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Boston Car Donation | Cars for Prostate Cancer

My wife has one of them new-fangled ?hybrid? cars. ?We?ll leave the specific company name out of it. Now- my mechanic, whom I love, in a very manly way, has made it clear to me that oil changes need to be done only every 5,000 miles. People who get paid for doing oil changes, including the dealers of that hybrid, want us to believe that it?s 3,000 miles.

My mechanic always puts a sticker in the upper left corner of my windshield to remind me when the 5,000 miles will be up. ?Here?s what the ?makers of the hybrid have done:

Maintaining Pancreatic Health

That light comes on every 3,000 miles. ?It doesn?t blink and then go off ? it?s STAYS on. The manufacturer knows that, in the normal cars we are all used to, such a message requires immediate action in order to avoid serious damage. Since we don?t have any idea how hybrids work, we will therefore run in and subject ourselves to whatever their mechanics decide to tell us needs to be done.

Lesson #1 for today ? Get a relationship with a mechanic you trust absolutely. ?If you need one in north Orange County, California, I can help.

Too bad our bodies don?t come with a ?Maintenance Required? light. There are so many things that can go wrong and there is so much ?Preventive Maintenance? that we can do, if only we remembered to do it.

Since we?re each on our own, please make a schedule to get your prostate, and everything else, maintained. We assume everything will continue as it is until, too often, the situation is so bad that there?s no hope. Finding prostate cancer after it has?metastasized?(spread to other organs) is the worst scenario.

Yes, we will take that hybrid off your hands. Your car donation enables us to spread the word of Prostate Awareness and gives you a nice tax donation.

Whether you?re in Boston or anywhere else, prostate cancer doesn?t go away.

Get your oil changed.

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Tuesday, April 3, 2012

Molecular mechanism contributing to cardiomyopathy elucidated

ScienceDaily (Apr. 1, 2012) ? Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown.

Professor Michael Gotthardt and Professor Norbert H?bner of the Max Delbr?ck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, and colleagues have found that the RNA binding motif protein 20 (RBM20), a gene previously tied to hereditary cardiomyopathy, regulates titin splicing. Understanding this molecular mechanism behind heart function and failure, could lead to more efficient molecular diagnosis and therapies for this sometimes insidious disease.

The ventricular filling of the heart is regulated by the different protein isoforms of titin which are produced through alternative splicing, a process in which the protein-coding regions of RNA (the exons) are connected in different ways, resulting in multiple mRNAs (messenger RNAs) that give rise to many proteins.

Professor Marion Greaser of the University of Wisconsin-Madison, USA, had recently identified a naturally occurring rat strain deficient in titin splicing, which resulted in an elongated titin protein. "Titin naturally shortens around birth as the blood flow is redirected through the heart," Professor Gotthardt explained, "but these rats maintained the excessively long embryonic titin isoforms, which suggests a cause for their cardiomyopathy."

Using genome-wide mapping techniques, the researchers found a loss-of-function mutation in RBM20 in all the rats that expressed the pathological titin isoform. The rats with this mutation also shared many phenotypic similarities with human patients suffering from RBM20 related cardiomyopathy; specifically, ventricular enlargement, arrhythmia, increased rate of sudden death, and extensive fibrosis.

The researchers also identified a set of 31 genes shared by humans and rats that regulate splicing with RBM20. Included in this group was titin, thus validating the group's previous findings. Many of these genes have previously been tied to cardiomyopathy, ion-homeostasis, and sarcomere biology and future analysis will help resolve their individual contribution to the progression of the disease.

Towards utilizing these findings in a clinical setting, Professor Gotthardt has developed a technique to characterize the functional consequences of individual RBM20 mutations. "We can help patients learn if their RBM20 mutation will likely result in the severe form of the disease so that their physician can devise an appropriate therapy," added Professor Gotthardt. "We are currently utilizing this information to develop novel therapeutic strategies for patients suffering from severe forms of cardiomyopathy."

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Story Source:

The above story is reprinted from materials provided by Helmholtz Association of German Research Centres.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Wei Guo, Sebastian Schafer, Marion L Greaser, Michael H Radke, Martin Liss, Thirupugal Govindarajan, Henrike Maatz, Herbert Schulz, Shijun Li, Amanda M Parrish, Vita Dauksaite, Padmanabhan Vakeel, Sabine Klaassen, Brenda Gerull, Ludwig Thierfelder, Vera Regitz-Zagrosek, Timothy A Hacker, Kurt W Saupe, G William Dec, Patrick T Ellinor, Calum A MacRae, Bastian Spallek, Robert Fischer, Andreas Perrot, Cemil ?zcelik, Kathrin Saar, Norbert Hubner, Michael Gotthardt. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nature Medicine, 2012; DOI: 10.1038/nm.2693

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Monday, April 2, 2012

SoFi Reinvents College Loans With Alumni Funding

sofiAs the cost of a college education continues to rise, a startup called SoFi is offering a way for alumni to offer students financial assistance and more. Co-founder and CEO Mike Cagney describes the current student loan system as a "classic market failure," resulting in students who are stuck with high interest rates and heavy debt that they struggle to pay off. He says that if you can remove government from the equation (specifically government loans)?and replace it with alumni, then "you create a very virtuous cycle."

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